Bioassay-guided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium

Extracts of Tanacetum parthenium are used in the prophylactic treatment of migraine and have also been used in Danish folk medicine for the treatment of epilepsy. An ethanol extract of T. parthenium showed high affinity for the GABAA-benzodiazepine site. An ethanol extract of T. parthenium was fract...

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Veröffentlicht in:	Phytotherapy research 2009-11, Vol.23 (11), p.1642-1644
Hauptverfasser:	Jäger, A.K, Krydsfeldt, K, Rasmussen, H.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apigenin Apigenin - isolation & purification Apigenin - pharmacology benzodiazepine site Biological and medical sciences Chromatography, High Pressure Liquid GABA General pharmacology Medical sciences Medicine, Traditional Parthenium Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - pharmacology Rats Receptors, GABA-A - drug effects Tanacetum Tanacetum parthenium Tanacetum parthenium - chemistry
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Zusammenfassung:	Extracts of Tanacetum parthenium are used in the prophylactic treatment of migraine and have also been used in Danish folk medicine for the treatment of epilepsy. An ethanol extract of T. parthenium showed high affinity for the GABAA-benzodiazepine site. An ethanol extract of T. parthenium was fractionated by VLC on silica and preparative C18 HPLC. Each step was monitored with the GABAA-benzodiazepine bioassay. The fractionation led to the isolation of apigenin, which may be responsible for CNS-effects of T. parthenium extracts. Copyright © 2009 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573 1099-1573
DOI:	10.1002/ptr.2816