Oral analgesia by non-steroidal anti-inflammatory drug zaltoprofen to manage cystoscopy-related pain: A prospective study

Objectives: To examine the pre‐emptive analgesic effect of the non‐steroidal anti‐inflammatory drug zaltoprofen against rigid cystoscopy‐associated pain, and compare it with the effect of an anesthetic gel. Methods: Forty men periodically undergoing follow‐up office cystoscopy were enrolled in this prospective study. The effects of lidocaine gel alone or in combination with zaltoprofen, were examined. The following parameters were assessed using an 11‐point numerical rating scale: pain during injection of gel into the urethra, insertion of rigid cystoscope, and the endoscopic examination of the urinary bladder, pain at the first urination after cystoscopy, and at the first urination in the following morning at home. Results: Pain scores with pre‐emptive zaltoprofen plus lidocaine gel were significantly lower than the ones with lidocaine gel alone at the time points of inserting rigid cystoscope into the urethra, viewing inside the urinary bladder and the first urination after cystoscopy. The efficacy of zaltoprofen was more significant in the patients with higher baseline pain score. There was no correlation between pain scores and bladder cancer grading, number of tumors, and time from surgery. Conclusions: Pre‐emptive zaltoprofen is able to control cystoscopy‐associated pain, which translates into better quality of life for patients. Thus, its use is recommended in the management of these patients.