Determination of pilocarpine by HPLC in presence of isopilocarpine a pH-sensitive polymer in ophthalmic dispersions
Quantification of pilocarpine in the presence of the epimer isopilocarpine in polymeric dispersions is reported. The method describes a technique using reversed-phase HPLC and UV detection of pilocarpine in the presence of a pH-sensitive polymer. As this method does not require prior sample preparat...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 1987, Vol.5 (4), p.379-382 |
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| container_end_page | 382 |
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| container_issue | 4 |
| container_start_page | 379 |
| container_title | Journal of pharmaceutical and biomedical analysis |
| container_volume | 5 |
| creator | Ibrahim, H. Boye, T. Wermeille, M. Gurny, R. Buri, P. |
| description | Quantification of pilocarpine in the presence of the epimer isopilocarpine in polymeric dispersions is reported. The method describes a technique using reversed-phase HPLC and UV detection of pilocarpine in the presence of a pH-sensitive polymer. As this method does not require prior sample preparation it will be of special interest for process control and development. |
| doi_str_mv | 10.1016/0731-7085(87)80044-4 |
| format | Article |
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The method describes a technique using reversed-phase HPLC and UV detection of pilocarpine in the presence of a pH-sensitive polymer. As this method does not require prior sample preparation it will be of special interest for process control and development.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/0731-7085(87)80044-4</identifier><identifier>PMID: 16867507</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Biological and medical sciences ; drug analysis ; General pharmacology ; isopilocarpine ; Medical sciences ; Pharmacology. 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The method describes a technique using reversed-phase HPLC and UV detection of pilocarpine in the presence of a pH-sensitive polymer. As this method does not require prior sample preparation it will be of special interest for process control and development.</description><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>drug analysis</subject><subject>General pharmacology</subject><subject>isopilocarpine</subject><subject>Medical sciences</subject><subject>Pharmacology. 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| fulltext | fulltext |
| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 1987, Vol.5 (4), p.379-382 |
| issn | 0731-7085 1873-264X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734110675 |
| source | Elsevier ScienceDirect Journals Complete |
| subjects | Analysis Biological and medical sciences drug analysis General pharmacology isopilocarpine Medical sciences Pharmacology. Drug treatments pilocarpine Reversed-phase HPLC UV detection |
| title | Determination of pilocarpine by HPLC in presence of isopilocarpine a pH-sensitive polymer in ophthalmic dispersions |
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