Determination of pilocarpine by HPLC in presence of isopilocarpine a pH-sensitive polymer in ophthalmic dispersions

Determination of pilocarpine by HPLC in presence of isopilocarpine a pH-sensitive polymer in ophthalmic dispersions

Quantification of pilocarpine in the presence of the epimer isopilocarpine in polymeric dispersions is reported. The method describes a technique using reversed-phase HPLC and UV detection of pilocarpine in the presence of a pH-sensitive polymer. As this method does not require prior sample preparat...

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Veröffentlicht in:Journal of pharmaceutical and biomedical analysis 1987, Vol.5 (4), p.379-382
Hauptverfasser: Ibrahim, H., Boye, T., Wermeille, M., Gurny, R., Buri, P.
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Biological and medical sciences
drug analysis
General pharmacology
isopilocarpine
Medical sciences
Pharmacology. Drug treatments
pilocarpine
Reversed-phase HPLC
UV detection
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Zusammenfassung:Quantification of pilocarpine in the presence of the epimer isopilocarpine in polymeric dispersions is reported. The method describes a technique using reversed-phase HPLC and UV detection of pilocarpine in the presence of a pH-sensitive polymer. As this method does not require prior sample preparation it will be of special interest for process control and development.
ISSN:0731-7085
1873-264X
DOI:10.1016/0731-7085(87)80044-4