Conventional and laser induced fluorescence detection of glucuronic acid conjugates after derivatization and liquid chromatographic separation

Conventional and laser induced fluorescence detection of glucuronic acid conjugates after derivatization and liquid chromatographic separation

Pre-chromatographic derivatisation of the carboxylic acid function of glucuronic acid conjugates is a suitable method for the selective and ultra-sensitive analysis of these compounds in urine and plasma samples. This goal is achieved by applying an indirect derivatisation procedure and laser induce...

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Veröffentlicht in:Journal of pharmaceutical and biomedical analysis 1988, Vol.6 (6), p.687-695
Hauptverfasser: Lingeman, H., Tjaden, U.R., Van Den Beld, C.M.B., Van Der Greef, J.
Format: Artikel
Sprache:eng
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conventional and laser induced fluorescence detection
derivatisation
glucuronic acid conjugates
Liquid chromatography
plasma and urine samples
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container_end_page 695
container_issue 6
container_start_page 687
container_title Journal of pharmaceutical and biomedical analysis
container_volume 6
creator Lingeman, H.
Tjaden, U.R.
Van Den Beld, C.M.B.
Van Der Greef, J.
description Pre-chromatographic derivatisation of the carboxylic acid function of glucuronic acid conjugates is a suitable method for the selective and ultra-sensitive analysis of these compounds in urine and plasma samples. This goal is achieved by applying an indirect derivatisation procedure and laser induced fluorescence detection with a homemade detection system equipped with a continuous-wave argon-ion laser. The minimum detectable amounts for the analytes, after derivatisation, are about 3 amol using the fluorescein fluorophore. In comparison with conventional induced fluorescence detection a gain in sensitivity of over four orders of magnitude is obtained.
doi_str_mv 10.1016/0731-7085(88)80080-3
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This goal is achieved by applying an indirect derivatisation procedure and laser induced fluorescence detection with a homemade detection system equipped with a continuous-wave argon-ion laser. The minimum detectable amounts for the analytes, after derivatisation, are about 3 amol using the fluorescein fluorophore. In comparison with conventional induced fluorescence detection a gain in sensitivity of over four orders of magnitude is obtained.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>16867332</pmid><doi>10.1016/0731-7085(88)80080-3</doi><tpages>9</tpages></addata></record>
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source Elsevier ScienceDirect Journals
subjects conventional and laser induced fluorescence detection
derivatisation
glucuronic acid conjugates
Liquid chromatography
plasma and urine samples
title Conventional and laser induced fluorescence detection of glucuronic acid conjugates after derivatization and liquid chromatographic separation
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