Simultaneous multiwavelength spectrophotometric quantitation of active components in analgesic formulations. Comparative study of three calculation methods

Simultaneous multiwavelength spectrophotometric quantitation of active components in analgesic formulations. Comparative study of three calculation methods

This work deals with the UV spectrophotometric quantitation of a mixture of compounds with overlapped spectra. The mixture spectrum is resolved by use of three computational programs based on different algorithms, namely Multicomponent Analysis (commercial software available from Hewlett-Packard), M...

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Veröffentlicht in:Journal of pharmaceutical and biomedical analysis 1988, Vol.6 (6), p.765-772
Hauptverfasser: Sala, G., Maspotch, S., Iturriaga, H., Blanco, M., Cerda, V.
Format: Artikel
Sprache:eng
Schlagworte:
acetaminophen
acetylsalicylic acid
analgesic analysis
caffeine
Multicomponent analysis
UV spectrophotometry
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Zusammenfassung:This work deals with the UV spectrophotometric quantitation of a mixture of compounds with overlapped spectra. The mixture spectrum is resolved by use of three computational programs based on different algorithms, namely Multicomponent Analysis (commercial software available from Hewlett-Packard), MULTIC (relying on multiple regression analysis) and SIMPLEX. The results obtained for mixtures of acetylsalicylic acid, acetaminophen and caffeine in commercial analgesic formulations, are compared.
ISSN:0731-7085
1873-264X
DOI:10.1016/0731-7085(88)80089-X