A new kinetic model for biochemical oscillations: Graph-theoretical analysis

A graphical analysis demonstrates the ability of slow substrate activation and certain types of cooperativity between the two enzyme active sites to generate sustained oscillations. The analysis allows us to estimate kinetic parameter values for which oscillations exist. The scheme analyzed can expl...

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Veröffentlicht in:	Biophysical chemistry 2009-12, Vol.145 (2), p.111-115
Hauptverfasser:	Goldstein, B.N., Aksirov, A.M., Zakrjevskaya, D.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalytic Domain Cooperativity Enzymes - chemistry Enzymes - metabolism Graph-theoretic method Kinetics Models, Biological Models, Chemical Substrate activation Sustained oscillation
Online-Zugang:	Volltext
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