A new kinetic model for biochemical oscillations: Graph-theoretical analysis

A new kinetic model for biochemical oscillations: Graph-theoretical analysis

A graphical analysis demonstrates the ability of slow substrate activation and certain types of cooperativity between the two enzyme active sites to generate sustained oscillations. The analysis allows us to estimate kinetic parameter values for which oscillations exist. The scheme analyzed can expl...

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Veröffentlicht in:Biophysical chemistry 2009-12, Vol.145 (2), p.111-115
Hauptverfasser: Goldstein, B.N., Aksirov, A.M., Zakrjevskaya, D.T.
Format: Artikel
Sprache:eng
Schlagworte:
Catalytic Domain
Cooperativity
Enzymes - chemistry
Enzymes - metabolism
Graph-theoretic method
Kinetics
Models, Biological
Models, Chemical
Substrate activation
Sustained oscillation
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Zusammenfassung:A graphical analysis demonstrates the ability of slow substrate activation and certain types of cooperativity between the two enzyme active sites to generate sustained oscillations. The analysis allows us to estimate kinetic parameter values for which oscillations exist. The scheme analyzed can explain the cyclical changes in functioning of various motor enzymes. Moreover, this scheme does not generate bistability for any parameter values. The graphical analysis presented is simple and visually clarifies the regulatory role of the details in the kinetic schemes.
ISSN:0301-4622
1873-4200
DOI:10.1016/j.bpc.2009.09.008