Impact of ACE and ApoE polymorphisms on myocardial perfusion: correlation with myocardial single photon emission computed tomographic imaging

Coronary artery disease is associated with multiple genetic and environmental risk factors. In this study, we evaluated the correlation of angiotensin l-converting enzyme (ACE) (I/D) and ApoE gene polymorphisms (E2, E3, E4 and g.-219G/T) with myocardial perfusion. We examined 410 patients using exer...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of human genetics 2009-10, Vol.54 (10), p.595-602
Hauptverfasser:	Georgoulias, Panagiotis, Wozniak, Greta, Samara, Maria, Chiotoglou, Ioanna, Kontos, Angelos, Tzavara, Chara, Valotassiou, Varvara, Georgitsi, Marianthi, Aleporou-Marinou, Vassiliki, Patrinos, George P, Kollia, Panagoula
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alleles Angiotensin Apolipoprotein E Apolipoproteins E - genetics Biomedical and Life Sciences Biomedicine Cardiovascular disease Computed tomography Coronary artery Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - genetics Coronary Circulation - genetics Exercise Test Female Gene Expression Gene Frequency Gene Function Gene Therapy Genotype Heart - diagnostic imaging Heart diseases Heterozygotes Homozygotes Human Genetics Humans Male Middle Aged Molecular Medicine Myocardial Perfusion Imaging - methods Organophosphorus Compounds Organotechnetium Compounds original-article Peptidyl-Dipeptidase A - genetics Perfusion Regression analysis Risk factors Single photon emission computed tomography Thallium Radioisotopes Tomography Tomography, Emission-Computed, Single-Photon
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Coronary artery disease is associated with multiple genetic and environmental risk factors. In this study, we evaluated the correlation of angiotensin l-converting enzyme (ACE) (I/D) and ApoE gene polymorphisms (E2, E3, E4 and g.-219G/T) with myocardial perfusion. We examined 410 patients using exercise–rest myocardial perfusion single photon emission computed tomography (SPECT), in which the summed stress score (SSS), summed rest score (SRS) and summed difference score (SDS) indexes were calculated. Homozygotes for the ACE D allele had greater mean values of SSS ( P
ISSN:	1434-5161 1435-232X
DOI:	10.1038/jhg.2009.83