Fmoc-protected, glycosylated asparagines potentially useful as reagents in the solid-phase synthesis of N-glycopeptides

Fmoc-protected, glycosylated asparagines potentially useful as reagents in the solid-phase synthesis of N-glycopeptides

1-Amino 1-deoxy derivatives of unprotected O-β- d-galactopyranosyl-(1 → 3)-2-acetamido-2-deoxy-β- d-glucopyranose, 2-acetamido-2-deoxy- that Fmoc-Asn(sugar)-OH derivatives are excellent candidates for automated synthesis of biologically active glycopeptides.

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Bibliographische Detailangaben
Veröffentlicht in:Carbohydrate research 1992-11, Vol.235, p.83-93
Hauptverfasser: Urge, Laszlo, Otvos, Laszlo, Lang, Emma, Wroblewski, Krzysztof, Laczko, Ilona, Hollosi, Miklos
Format: Artikel
Sprache:eng
Schlagworte:
Asparagine - analogs & derivatives
Carbohydrate Conformation
Carbohydrate Sequence
Carbohydrates
Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides
Carbohydrates. Nucleosides and nucleotides
Chemistry
Disaccharides
Exact sciences and technology
Glycopeptides - chemical synthesis
Glycosylation
Indicators and Reagents
Molecular Sequence Data
Organic chemistry
Preparations and properties
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Beschreibung
Zusammenfassung:1-Amino 1-deoxy derivatives of unprotected O-β- d-galactopyranosyl-(1 → 3)-2-acetamido-2-deoxy-β- d-glucopyranose, 2-acetamido-2-deoxy- that Fmoc-Asn(sugar)-OH derivatives are excellent candidates for automated synthesis of biologically active glycopeptides.
ISSN:0008-6215
1873-426X
DOI:10.1016/0008-6215(92)80080-K