Etiology of chest wall deformities—a genetic review for the treating physician

Abstract Chest wall deformities such as pectus excavatum, pectus carinatum, and cleft sternum can be isolated malformations or dysmorphic features of genetic associations, monogenic disorders, and various numeric and structural chromosomal aberrations. In contrast to the most important syndromes suc...

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Veröffentlicht in:Journal of pediatric surgery 2009-10, Vol.44 (10), p.2004-2011
Hauptverfasser: Kotzot, Dieter, Schwabegger, Anton H
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract Chest wall deformities such as pectus excavatum, pectus carinatum, and cleft sternum can be isolated malformations or dysmorphic features of genetic associations, monogenic disorders, and various numeric and structural chromosomal aberrations. In contrast to the most important syndromes such as Marfan syndrome or Noonan syndrome that can be associated with a chest wall deformity and for which the causative genes are known, etiology of isolated chest wall deformities is still a matter of research. Therefore, an interdisciplinary approach, particularly in patients with additional symptoms is strongly recommended to choose the best therapeutic approach for each patient and its family.
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2009.07.029