Imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1

Synthesis of several novel imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1 are described. Synthesis of several novel imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV are described. Synthetic approaches a...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-11, Vol.19 (22), p.6399-6403
Hauptverfasser:	Gudmundsson, Kristjan S., Boggs, Sharon D., Catalano, John G., Svolto, Angilique, Spaltenstein, Andrew, Thomson, Michael, Wheelan, Pat, Jenkinson, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - pharmacokinetics Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Antiviral agents Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Biological and medical sciences Cell Line, Tumor CXCR4 HIV HIV - chemistry HIV Infections - drug therapy HIV-1 - drug effects Human immunodeficiency virus Human immunodeficiency virus 1 Humans Imidazopyridine Medical sciences Models, Chemical Pharmacology. Drug treatments Tetrahydroquinoline
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Zusammenfassung:	Synthesis of several novel imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1 are described. Synthesis of several novel imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV are described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity and pharmacokinetics are highlighted. Several compounds with low nanomolar anti-HIV activity and oral bioavailability are described.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2009.09.056