Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens

Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens

Stand and deliver: Degradable polyelectrolyte microcapsules (PMs; see picture) as antigen delivery vehicles are taken up by dendritic cells (DCs) by macropinocytosis. Following uptake, the shell of the microcapsules ruptures, resulting in the invasion of the capsules by the cellular cytoplasm, thus...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2009-10, Vol.48 (45), p.8485-8489
Hauptverfasser: De Koker, Stefaan, De Geest, Bruno G, Singh, Satwinder K, De Rycke, Riet, Naessens, Thomas, Van Kooyk, Yvette, Demeester, Jo, De Smedt, Stefaan C, Grooten, Johan
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antigen Presentation
antigens
Antigens - administration & dosage
Antigens - immunology
capsules
Capsules - chemistry
Cross-Priming
dendritic cells
Dendritic Cells - immunology
Electrolytes - chemistry
Mice
polyelectrolytes
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Beschreibung
Zusammenfassung:Stand and deliver: Degradable polyelectrolyte microcapsules (PMs; see picture) as antigen delivery vehicles are taken up by dendritic cells (DCs) by macropinocytosis. Following uptake, the shell of the microcapsules ruptures, resulting in the invasion of the capsules by the cellular cytoplasm, thus allowing DCs to efficiently process encapsulated antigen.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200903769