5-HT4 receptors, present in piglet atria and sensitive to SDZ 205-557, are absent in papillary muscle

Putative 5-HT4 receptors were investigated in isolated piglet left atria and papillary muscles. In atrial tissues, 5-hydroxytryptamine (5-HT) was a potent positive inotropic agent with a pD2 of 6.7. Its effects were antagonised in a selective and competitive manner by the 5-HT4 receptor antagonist,...

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Veröffentlicht in:	European journal of pharmacology 1992-12, Vol.229 (1), p.105-108
Hauptverfasser:	LORRAIN, J, GROSSET, A, O'CONNOR, S. E
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminobenzoic Acid - pharmacology Animals Biological and medical sciences Cardiotonic Agents - pharmacology Female Fundamental and applied biological sciences. Psychology Heart Heart Atria - drug effects In Vitro Techniques Male Papillary Muscles - drug effects para-Aminobenzoates Receptors, Serotonin - classification Receptors, Serotonin - physiology Serotonin - pharmacology Serotonin Antagonists Swine Vertebrates: cardiovascular system
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Zusammenfassung:	Putative 5-HT4 receptors were investigated in isolated piglet left atria and papillary muscles. In atrial tissues, 5-hydroxytryptamine (5-HT) was a potent positive inotropic agent with a pD2 of 6.7. Its effects were antagonised in a selective and competitive manner by the 5-HT4 receptor antagonist, SDZ 205-557, with a pA2 of 7.3. In contrast to atrial tissues, piglet papillary muscles were virtually unresponsive to 5-HT 10(-8)-10(-3) M, suggesting that functional cardiac 5-HT4 receptors are not present in ventricular tissue.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(92)90293-D