Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation

Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation

Interstrand cross-linking (ICL) forming oligodeoxynucleotides (ODNs) have been expected to ensure the inhibition of gene expression. In this communication, we report a highly efficient and selective ICL reaction to thymine using a 4-amino-2-vinyl-6-oxopyrimidine derivative.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2009-01 (42), p.6463-6465
Hauptverfasser: Hattori, Keiichi, Hirohama, Tomoya, Imoto, Shuhei, Kusano, Shuhei, Nagatsugi, Fumi
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Interstrand cross-linking (ICL) forming oligodeoxynucleotides (ODNs) have been expected to ensure the inhibition of gene expression. In this communication, we report a highly efficient and selective ICL reaction to thymine using a 4-amino-2-vinyl-6-oxopyrimidine derivative.
ISSN:1359-7345
1364-548X
DOI:10.1039/b915381k