MRI contrast agent delivery using spore capsules: controlled release in blood plasma

MRI contrast agent delivery using spore capsules: controlled release in blood plasma

The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is slowly released in plasma due to enzymatic digestion...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2009-11 (42), p.6442-6444
Hauptverfasser: Lorch, Mark, Thomasson, Matthew J, Diego-Taboada, Alberto, Barrier, Sylvain, Atkin, Stephen L, Mackenzie, Grahame, Archibald, Stephen J
Format: Artikel
Sprache:eng
Schlagworte:
Biopolymers - chemistry
Carotenoids - chemistry
Contrast Media - chemistry
Drug Carriers - chemistry
Gadolinium DTPA - blood
Gadolinium DTPA - chemistry
Magnetic Resonance Imaging
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Zusammenfassung:The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is slowly released in plasma due to enzymatic digestion of the capsule.
ISSN:1364-548X
DOI:10.1039/b909551a