Novel l-Xylose Derivatives as Selective Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes

The prevalence of diabetes throughout the world continues to increase and has become a major health issue. Recently there have been several reports of inhibitors directed toward the sodium-dependent glucose cotransporter 2 (SGLT2) as a method of maintaining glucose homeostasis in diabetic patients....

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Veröffentlicht in:	Journal of medicinal chemistry 2009-10, Vol.52 (20), p.6201-6204
Hauptverfasser:	Goodwin, Nicole C, Mabon, Ross, Harrison, Bryce A, Shadoan, Melanie K, Almstead, Zheng Y, Xie, Yiling, Healy, Jason, Buhring, Lindsey M, DaCosta, Christopher M, Bardenhagen, Jennifer, Mseeh, Faika, Liu, Qingyun, Nouraldeen, Amr, Wilson, Alan G. E, Kimball, S. David, Powell, David R, Rawlins, David B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - urine Drug Discovery General and cellular metabolism. Vitamins Glucose - metabolism Humans Medical sciences Mice Pharmacology. Drug treatments Sodium-Glucose Transporter 2 - antagonists & inhibitors Substrate Specificity Xylose - administration & dosage Xylose - analogs & derivatives Xylose - pharmacology Xylose - therapeutic use
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Zusammenfassung:	The prevalence of diabetes throughout the world continues to increase and has become a major health issue. Recently there have been several reports of inhibitors directed toward the sodium-dependent glucose cotransporter 2 (SGLT2) as a method of maintaining glucose homeostasis in diabetic patients. Herein we report the discovery of the novel O-xyloside 7c that inhibits SGLT2 in vitro and urinary glucose reabsorption in vivo.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm900951n