Effect of hydrotalcite-like compounds on the aqueous solubility of some poorly water-soluble drugs
A new approach of improving drug dissolution properties is described. This method exploits the property of a carrier owing to the hydrotalcite-type anionic clays (HTlc). HTlc is an inorganic layered solid that lodges anionic compounds among its layers. As HTlc dissolves at acidic pH values (pH
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| Veröffentlicht in: | Journal of pharmaceutical sciences 2003-07, Vol.92 (7), p.1407-1418 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | Ambrogi, Valeria Fardella, Giuseppe Grandolini, Giuliano Nocchetti, Morena Perioli, Luana |
| description | A new approach of improving drug dissolution properties is described. This method exploits the property of a carrier owing to the hydrotalcite-type anionic clays (HTlc). HTlc is an inorganic layered solid that lodges anionic compounds among its layers. As HTlc dissolves at acidic pH values (pH |
| doi_str_mv | 10.1002/jps.10411 |
| format | Article |
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This method exploits the property of a carrier owing to the hydrotalcite-type anionic clays (HTlc). HTlc is an inorganic layered solid that lodges anionic compounds among its layers. As HTlc dissolves at acidic pH values (pH<4), the anions intercalated among the layers are promptly released in the medium. In this article some nonsteroidal antiinflammatory drugs were chosen as models of poorly water-soluble drugs. They were intercalated in HTlc and solubility measurements in acidic medium were performed. A remarkable improvement of drug solubility was observed especially in the case of indomethacin.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.10411</identifier><identifier>PMID: 12820145</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Aluminum Hydroxide - analysis ; Aluminum Hydroxide - chemistry ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; General pharmacology ; hydrotalcite ; intercalation compound ; Magnesium Hydroxide - analysis ; Magnesium Hydroxide - chemistry ; Medical sciences ; Pharmaceutical Preparations - analysis ; Pharmaceutical Preparations - chemistry ; Pharmacology. Drug treatments ; Physicochemical properties. Structure-activity relationships ; poorly water-soluble drug ; solubility ; Solubility - drug effects ; Spectroscopy, Fourier Transform Infrared - methods ; Thermogravimetry - methods ; Water - analysis ; Water - chemistry</subject><ispartof>Journal of pharmaceutical sciences, 2003-07, Vol.92 (7), p.1407-1418</ispartof><rights>2003 Wiley-Liss, Inc.</rights><rights>Copyright © 2003 Wiley‐Liss, Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 Wiley-Liss, Inc. and the American Pharmacists Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4991-17751eb6a67115481ee2b0a62e623cfcb2d7aed93a1e14a5732d8565b3dc03923</citedby><cites>FETCH-LOGICAL-c4991-17751eb6a67115481ee2b0a62e623cfcb2d7aed93a1e14a5732d8565b3dc03923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.10411$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.10411$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14938976$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12820145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ambrogi, Valeria</creatorcontrib><creatorcontrib>Fardella, Giuseppe</creatorcontrib><creatorcontrib>Grandolini, Giuliano</creatorcontrib><creatorcontrib>Nocchetti, Morena</creatorcontrib><creatorcontrib>Perioli, Luana</creatorcontrib><title>Effect of hydrotalcite-like compounds on the aqueous solubility of some poorly water-soluble drugs</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>A new approach of improving drug dissolution properties is described. This method exploits the property of a carrier owing to the hydrotalcite-type anionic clays (HTlc). HTlc is an inorganic layered solid that lodges anionic compounds among its layers. As HTlc dissolves at acidic pH values (pH<4), the anions intercalated among the layers are promptly released in the medium. In this article some nonsteroidal antiinflammatory drugs were chosen as models of poorly water-soluble drugs. They were intercalated in HTlc and solubility measurements in acidic medium were performed. A remarkable improvement of drug solubility was observed especially in the case of indomethacin.</description><subject>Aluminum Hydroxide - analysis</subject><subject>Aluminum Hydroxide - chemistry</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>General pharmacology</subject><subject>hydrotalcite</subject><subject>intercalation compound</subject><subject>Magnesium Hydroxide - analysis</subject><subject>Magnesium Hydroxide - chemistry</subject><subject>Medical sciences</subject><subject>Pharmaceutical Preparations - analysis</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemical properties. Structure-activity relationships</subject><subject>poorly water-soluble drug</subject><subject>solubility</subject><subject>Solubility - drug effects</subject><subject>Spectroscopy, Fourier Transform Infrared - methods</subject><subject>Thermogravimetry - methods</subject><subject>Water - analysis</subject><subject>Water - chemistry</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtv1TAQRi0EoreFBX8AeQNSF6F-xHayhNIHqAIkoCwtx5lQt04c7ISSf49vc6EbWNnSnG9mfIzQM0peUULY0fWY8qWk9AHaUMFIIQlVD9Em11jBRVnvof2UrgkhkgjxGO1RVjFCS7FBzUnXgZ1w6PDV0sYwGW_dBIV3N4Bt6McwD23CYcDTFWDzY4YwJ5yCnxvn3bRsgyn0gMcQol_wrZkgFnd1D7iN8_f0BD3qjE_wdHceoK-nJ1-Oz4uLj2fvjl9fFLasa1pQpQSFRhqpKBVlRQFYQ4xkIBm3nW1Yqwy0NTcUaGmE4qythBQNby3hNeMH6OXad4wh75km3btkwXszbJfWipekEpXI4OEK2hhSitDpMbrexEVTordCdRaq74Rm9vmu6dz00N6TO4MZeLEDTLLGd9EM1qV7rqx5VSuZuaOVu3Uelv9P1O8_ff4zulgTLk3w62_CxBstFVdCf_twpuvLcyFPL9_ot5nnKw9Z8k8HUSfrYLDQupi_WLfB_eOBvwGTHa34</recordid><startdate>200307</startdate><enddate>200307</enddate><creator>Ambrogi, Valeria</creator><creator>Fardella, Giuseppe</creator><creator>Grandolini, Giuliano</creator><creator>Nocchetti, Morena</creator><creator>Perioli, Luana</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200307</creationdate><title>Effect of hydrotalcite-like compounds on the aqueous solubility of some poorly water-soluble drugs</title><author>Ambrogi, Valeria ; Fardella, Giuseppe ; Grandolini, Giuliano ; Nocchetti, Morena ; Perioli, Luana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4991-17751eb6a67115481ee2b0a62e623cfcb2d7aed93a1e14a5732d8565b3dc03923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aluminum Hydroxide - analysis</topic><topic>Aluminum Hydroxide - chemistry</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>General pharmacology</topic><topic>hydrotalcite</topic><topic>intercalation compound</topic><topic>Magnesium Hydroxide - analysis</topic><topic>Magnesium Hydroxide - chemistry</topic><topic>Medical sciences</topic><topic>Pharmaceutical Preparations - analysis</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemical properties. 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Pharm. Sci</addtitle><date>2003-07</date><risdate>2003</risdate><volume>92</volume><issue>7</issue><spage>1407</spage><epage>1418</epage><pages>1407-1418</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>A new approach of improving drug dissolution properties is described. This method exploits the property of a carrier owing to the hydrotalcite-type anionic clays (HTlc). HTlc is an inorganic layered solid that lodges anionic compounds among its layers. As HTlc dissolves at acidic pH values (pH<4), the anions intercalated among the layers are promptly released in the medium. In this article some nonsteroidal antiinflammatory drugs were chosen as models of poorly water-soluble drugs. They were intercalated in HTlc and solubility measurements in acidic medium were performed. A remarkable improvement of drug solubility was observed especially in the case of indomethacin.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><pmid>12820145</pmid><doi>10.1002/jps.10411</doi><tpages>12</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Aluminum Hydroxide - analysis Aluminum Hydroxide - chemistry Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents General pharmacology hydrotalcite intercalation compound Magnesium Hydroxide - analysis Magnesium Hydroxide - chemistry Medical sciences Pharmaceutical Preparations - analysis Pharmaceutical Preparations - chemistry Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships poorly water-soluble drug solubility Solubility - drug effects Spectroscopy, Fourier Transform Infrared - methods Thermogravimetry - methods Water - analysis Water - chemistry |
| title | Effect of hydrotalcite-like compounds on the aqueous solubility of some poorly water-soluble drugs |
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