Effect of hydrotalcite-like compounds on the aqueous solubility of some poorly water-soluble drugs

A new approach of improving drug dissolution properties is described. This method exploits the property of a carrier owing to the hydrotalcite-type anionic clays (HTlc). HTlc is an inorganic layered solid that lodges anionic compounds among its layers. As HTlc dissolves at acidic pH values (pH

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 2003-07, Vol.92 (7), p.1407-1418
Hauptverfasser:	Ambrogi, Valeria, Fardella, Giuseppe, Grandolini, Giuliano, Nocchetti, Morena, Perioli, Luana
Format:	Artikel
Sprache:	eng
Schlagworte:	Aluminum Hydroxide - analysis Aluminum Hydroxide - chemistry Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents General pharmacology hydrotalcite intercalation compound Magnesium Hydroxide - analysis Magnesium Hydroxide - chemistry Medical sciences Pharmaceutical Preparations - analysis Pharmaceutical Preparations - chemistry Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships poorly water-soluble drug solubility Solubility - drug effects Spectroscopy, Fourier Transform Infrared - methods Thermogravimetry - methods Water - analysis Water - chemistry
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Beschreibung
Zusammenfassung:	A new approach of improving drug dissolution properties is described. This method exploits the property of a carrier owing to the hydrotalcite-type anionic clays (HTlc). HTlc is an inorganic layered solid that lodges anionic compounds among its layers. As HTlc dissolves at acidic pH values (pH
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.10411