Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid beta peptide

Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid beta peptide

Covalently cross-linked homodimeric Abeta peptides have been prepared by solid-phase peptide synthesis by exploiting 'site-site interactions', and exhibit substantially increased oligomerisation and fibrillisation properties compared with the corresponding monomers.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2009-01 (41), p.6228-6230
Hauptverfasser: Kok, W Mei, Scanlon, Denis B, Karas, John A, Miles, Luke A, Tew, Deborah J, Parker, Michael W, Barnham, Kevin J, Hutton, Craig A
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Amyloid beta-Peptides - chemical synthesis
Amyloid beta-Peptides - chemistry
Cross-Linking Reagents
Molecular Sequence Data
Protein Multimerization
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Beschreibung
Zusammenfassung:Covalently cross-linked homodimeric Abeta peptides have been prepared by solid-phase peptide synthesis by exploiting 'site-site interactions', and exhibit substantially increased oligomerisation and fibrillisation properties compared with the corresponding monomers.
ISSN:1359-7345
1364-548X
DOI:10.1039/b912784d