Infection by the Sylvio X10/4 clone of Trypanosoma cruzi: relevance of a low-virulence model of Chagas' disease

The physiopathology of Chagas' disease has been largely defined in murine infections with virulent strains which partially represent parasite diversity. This report reviews our studies with Sylvio X10/4 parasites, a Trypanosoma cruzi clone that induces no acute phase but in C3H/He mice leads to...

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Veröffentlicht in:	Microbes and infection 2009-11, Vol.11 (13), p.1037-1045
Hauptverfasser:	Marinho, Cláudio R.F., Nuñez-Apaza, Luis N., Bortoluci, Karina R., Bombeiro, André L., Bucci, Daniella Z., Grisotto, Marcos G., Sardinha, Luiz R., Jorquera, Christian E., Lira, Sergio, D'Império Lima, Maria Regina, Álvarez, José M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chagas Disease - immunology Chagas Disease - parasitology Chagas' disease Chronic Disease Disease Models, Animal Fundamental and applied biological sciences. Psychology Heart pathology Host-Parasite Interactions Human protozoal diseases Immune response Infectious diseases Life cycle. Host-agent relationship. Pathogenesis Medical sciences Mice Microbiology Parasitaemia Parasite evasion Parasitemia - immunology Parasitemia - parasitology Parasitic diseases Protozoa Protozoal diseases Sylvio X10/4 parasites Trypanosoma cruzi Trypanosoma cruzi - pathogenicity Trypanosoma cruzi - physiology Trypanosomiasis
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Zusammenfassung:	The physiopathology of Chagas' disease has been largely defined in murine infections with virulent strains which partially represent parasite diversity. This report reviews our studies with Sylvio X10/4 parasites, a Trypanosoma cruzi clone that induces no acute phase but in C3H/He mice leads to chronic myocarditis resembling the human disease.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/j.micinf.2009.07.011