Effect of Metoprolol on Quality of Life in the Prevention of Syncope Trial

Introduction: Vasovagal syncope is common, often recurrent, and reduces quality of life. No therapies have proven useful to improve quality of life in adequately designed randomized clinical trials. Beta‐blockers have mixed evidence for effectiveness in preventing syncope. Methods: The Prevention of Syncope Trial was a randomized, placebo‐controlled, double‐blind, multinational, clinical trial that tested the hypothesis that metoprolol improves quality of life in adult patients with vasovagal syncope in a 1‐year observation period. Randomization was stratified in strata of patients