Very High Serum CA 19-9 Levels: A Contraindication to Pancreaticoduodenectomy?

Aim To assess the outcome of patients with resectable pancreatic adenocarcinoma (PA) associated with high serum CA 19-9 levels. Methods From 2000 to 2007, 344 patients underwent pancreatoduodenectomy for PA. Fifty-three patients ( elevated group) had preoperatively elevated serum CA 19-9 levels (>...

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Veröffentlicht in:	Journal of gastrointestinal surgery 2009-10, Vol.13 (10), p.1791-1797
Hauptverfasser:	Turrini, O., Schmidt, C. M., Moreno, J., Parikh, P., Matos, J. M., House, M. G., Zyromski, N. J., Nakeeb, A., Pitt, H. A., Lillemoe, K. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	2008 SSAT Poster Presentation Adenocarcinoma - blood Adenocarcinoma - surgery Aged Aged, 80 and over Biomarkers, Tumor - blood CA-19-9 Antigen - blood Contraindications Female Gastroenterology Humans Male Medical research Medicine Medicine & Public Health Middle Aged Pancreatic Neoplasms - blood Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Pancreaticoduodenectomy Postoperative Period Predictive Value of Tests Preoperative Period Prognosis Surgery Survival Analysis Treatment Outcome
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Zusammenfassung:	Aim To assess the outcome of patients with resectable pancreatic adenocarcinoma (PA) associated with high serum CA 19-9 levels. Methods From 2000 to 2007, 344 patients underwent pancreatoduodenectomy for PA. Fifty-three patients ( elevated group) had preoperatively elevated serum CA 19-9 levels (>400 IU/ml) after resolution of obstructive jaundice. Of these, 27 patients had high levels (400–899 IU/ml (HL)) and 26 patients had very high levels ≥900 IU/ml (VHL). Fifty patients with normal preoperative serum CA 19-9 levels (
ISSN:	1091-255X 1873-4626
DOI:	10.1007/s11605-009-0916-5