Neuroprotective profile of dextromethorphan in an experimental model of penetrating ballistic-like brain injury

Dextromethorphan (DM) has been well-characterized as a neuroprotective agent in experimental models of CNS injury. The goal of this study was to determine the neuroprotective profile of DM in a military-relevant model of penetrating ballistic-like brain injury (PBBI). In an acute (3 day) dose–respon...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2009-11, Vol.94 (1), p.56-62
Hauptverfasser:	Shear, Deborah A., Williams, Anthony J., Sharrow, Keith, Lu, Xi-Chun M., Tortella, Frank C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Analysis of Variance Animals Behavior, Animal - drug effects Biological and medical sciences Brain Injuries - drug therapy Brain Injuries - pathology Brain Injuries - surgery Cognition - drug effects Cognitive Dextromethorphan Dextromethorphan - administration & dosage Dextromethorphan - therapeutic use Diffuse Axonal Injury - pathology Dose-Response Relationship, Drug Frontal Lobe - drug effects Frontal Lobe - injuries Frontal Lobe - surgery Head Injuries, Penetrating - drug therapy Head Injuries, Penetrating - pathology Head Injuries, Penetrating - surgery Image Processing, Computer-Assisted Injuries of the nervous system and the skull. Diseases due to physical agents Male Medical sciences Motor Motor Activity - drug effects Nerve Degeneration - pathology Neuroprotective Agents - administration & dosage Neuroprotective Agents - therapeutic use NOR Novel object recognition Organic mental disorders. Neuropsychology PBBI Penetrating ballistic-like brain injury Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rats Rats, Sprague-Dawley Recognition (Psychology) - drug effects TBI Time Factors Traumas. Diseases due to physical agents Traumatic brain injury
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