Attenuation of proteolysis and muscle wasting by curcumin c3 complex in MAC16 colon tumour-bearing mice

Muscle wasting or cachexia is caused by accelerated muscle protein breakdown via the ubiquitin–proteasome complex. We investigated the effect of curcumin c3 complex (curcumin c3) on attenuation of muscle proteolysis using in vitro and in vivo models. Our in vitro data indicate that curcumin c3 as lo...

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Veröffentlicht in:	British journal of nutrition 2009-10, Vol.102 (7), p.967-975
Hauptverfasser:	Siddiqui, Rafat A., Hassan, Samira, Harvey, Kevin A., Rasool, Tamkeen, Das, Tapas, Mukerji, Pradip, DeMichele, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Biological and medical sciences Body weight Cachexia Cachexia - etiology Cachexia - physiopathology Cachexia - prevention & control cell lines Cells, Cultured Colonic Neoplasms - complications Colorectal cancer colorectal neoplasms Curcumin Curcumin - pharmacology Curcumin - therapeutic use curcumin c3 complex Dietary supplements Dose-Response Relationship, Drug Drug Evaluation, Preclinical - methods Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology gene expression Humans MAC16 cell lines MAC16 tumours Mice Molecular Nutrition Muscle Fibers, Skeletal - pathology Muscle Proteins - metabolism Muscle wasting Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscular Atrophy - etiology Muscular Atrophy - pathology Muscular Atrophy - prevention & control muscular diseases Muscular system Myoblasts - drug effects Myoblasts - pathology Nutrition research Phytochemicals Proteasome Endopeptidase Complex - metabolism Proteasomes protective effect proteolysis Rodents ubiquitin Vertebrates: anatomy and physiology, studies on body, several organs or systems Weight Loss - drug effects Xenograft Model Antitumor Assays
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Zusammenfassung:	Muscle wasting or cachexia is caused by accelerated muscle protein breakdown via the ubiquitin–proteasome complex. We investigated the effect of curcumin c3 complex (curcumin c3) on attenuation of muscle proteolysis using in vitro and in vivo models. Our in vitro data indicate that curcumin c3 as low as 0·50 μg/ml was very effective in significantly inhibiting (30 %; P
ISSN:	0007-1145 1475-2662
DOI:	10.1017/S0007114509345250