Interplay Between Weight Loss and Gut Microbiota Composition in Overweight Adolescents

The aim of this study was to determine the influence of an obesity treatment program on the gut microbiota and body weight of overweight adolescents. Thirty‐six adolescents (13–15 years), classified as overweight according to the International Obesity Task Force BMI criteria, were submitted to a cal...

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Veröffentlicht in:	Obesity (Silver Spring, Md.) Md.), 2009-10, Vol.17 (10), p.1906-1915
Hauptverfasser:	Santacruz, Arlette, Marcos, Ascensión, Wärnberg, Julia, Martí, Amelia, Martin-Matillas, Miguel, Campoy, Cristina, Moreno, Luis A, Veiga, Oscar, Redondo-Figuero, Carlos, Garagorri, Jesús M, Azcona, Cristina, Delgado, Manuel, García-Fuentes, Miguel, Collado, Maria C, Sanz, Yolanda
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent adolescent nutrition adolescents body mass index Caloric Restriction Calories Clinical trials Diet Dietary restrictions DNA primers DNA, Bacterial - chemistry DNA, Bacterial - genetics Exercise feces Feces - microbiology Female Gastrointestinal Tract - microbiology Humans intestinal microorganisms lactic acid bacteria low calorie diet Male microbial genetics Microbiota molecular sequence data Nutrition research nutritional intervention Obesity Obesity - microbiology Overweight physical activity Polymerase Chain Reaction probiotics Statistics, Nonparametric Task forces Teenagers Weight control weight loss Weight Loss - physiology
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Zusammenfassung:	The aim of this study was to determine the influence of an obesity treatment program on the gut microbiota and body weight of overweight adolescents. Thirty‐six adolescents (13–15 years), classified as overweight according to the International Obesity Task Force BMI criteria, were submitted to a calorie‐restricted diet (10–40%) and increased physical activity (15–23 kcal/kg body weight/week) program over 10 weeks. Gut bacterial groups were analyzed by quantitative real‐time PCR before and after the intervention. A group of subjects (n = 23) experienced >4.0 kg weight loss and showed significant BMI (P = 0.030) and BMI z‐score (P = 0.035) reductions after the intervention, while the other group (n = 13) showed
ISSN:	1930-7381 1930-739X
DOI:	10.1038/oby.2009.112