One-Pot Synthesis of 2-Pyridones via Chemo- and Regioselective Tandem Blaise Reaction of Nitriles with Propiolates

The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of organic chemistry 2009-10, Vol.74 (19), p.7556-7558
Hauptverfasser:	Chun, Yu Sung, Ryu, Ka Yeon, Ko, Young Ok, Hong, Joo Yeon, Hong, Jongki, Shin, Hyunik, Lee, Sang-gi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Molecular Structure Nitriles - chemistry Organic chemistry Organometallic Compounds - chemistry Preparations and properties Propionates - chemistry Pyridones - chemical synthesis Pyridones - chemistry Stereoisomerism Zinc - chemistry
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Beschreibung
Zusammenfassung:	The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo901642t