Cationic Hypericin Derivatives as Novel Agents with Photobactericidal Activity: Synthesis and Photodynamic Inactivation of Propionibacterium acnes

Cationic Hypericin Derivatives as Novel Agents with Photobactericidal Activity: Synthesis and Photodynamic Inactivation of Propionibacterium acnes

The present communication describes for the first time the synthesis and preliminary testing of two cationic hypericin derivatives. Uncharged hypericin derivatives with ω,ω’‐attached C2‐linkers leading to a pyridyl or a 4‐dimethylaminophenyl residue were prepared and subsequently quaternized by mean...

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Veröffentlicht in:Photochemistry and photobiology 2009-09, Vol.85 (5), p.1201-1206
Hauptverfasser: Hager, Beate, Strauss, Wolfgang S. L., Falk, Heinz
Format: Artikel
Sprache:eng
Schlagworte:
Acne
Anti-Bacterial Agents - pharmacology
Cations
Fluorescence
Gram-positive bacteria
Perylene - analogs & derivatives
Perylene - pharmacology
Photochemotherapy
Photodynamic therapy
Propionibacterium acnes - drug effects
Regulatory approval
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Zusammenfassung:The present communication describes for the first time the synthesis and preliminary testing of two cationic hypericin derivatives. Uncharged hypericin derivatives with ω,ω’‐attached C2‐linkers leading to a pyridyl or a 4‐dimethylaminophenyl residue were prepared and subsequently quaternized by means of iodomethane. Photobactericidal activity was assessed using Propionibacterium acnes. The quaternary N,N,N‐trimethyl‐anilinium derivative displayed a pronounced photodynamic inactivation of the bacteria at low incubation concentrations (
ISSN:0031-8655
1751-1097
DOI:10.1111/j.1751-1097.2009.00587.x