Shape and Release Control of a Peptide Decorated Vesicle through pH Sensitive Orthogonal Supramolecular Interactions

Shape and Release Control of a Peptide Decorated Vesicle through pH Sensitive Orthogonal Supramolecular Interactions

A pH sensitive carrier is obtained by coating a cyclodextrin vesicle with an adamantane-terminated octapeptide through the formation of an inclusion complex. Upon lowering the pH from 7.4 to 5.0, the formation of peptide β-sheets on the vesicle surface induces a transition of the bilayer from a sphe...

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Veröffentlicht in:Journal of the American Chemical Society 2009-09, Vol.131 (37), p.13186-13187
Hauptverfasser: Versluis, Frank, Tomatsu, Itsuro, Kehr, Seda, Fregonese, Carlo, Tepper, Armand W.J.W, Stuart, Marc C. A, Ravoo, Bart Jan, Koning, Roman I, Kros, Alexander
Format: Artikel
Sprache:eng
Schlagworte:
Circular Dichroism
Cyclodextrins - chemistry
Fluorescent Dyes - chemistry
Hydrogen-Ion Concentration
Membranes, Artificial
Oligopeptides - chemistry
Protein Structure, Secondary
Surface Properties
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Zusammenfassung:A pH sensitive carrier is obtained by coating a cyclodextrin vesicle with an adamantane-terminated octapeptide through the formation of an inclusion complex. Upon lowering the pH from 7.4 to 5.0, the formation of peptide β-sheets on the vesicle surface induces a transition of the bilayer from a sphere to a fiber. This transition is fully reversible and repeatable. The vesicles release their cargo upon fiber formation.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja9026264