Surface-Mediated DNA Self-Assembly

Surface-Mediated DNA Self-Assembly

This communication reports a strategy for solid surface-mediated DNA self-assembly. DNA molecules weakly interact with solid surfaces; thus are confined to solid surfaces. The confinement reduces the flexibility of DNA nanomotifs and promotes the DNA 2D crystals to grow on solid surfaces. As a demon...

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Veröffentlicht in:Journal of the American Chemical Society 2009-09, Vol.131 (37), p.13248-13249
Hauptverfasser: Sun, Xuping, Hyeon Ko, Seung, Zhang, Chuan, Ribbe, Alexander E, Mao, Chengde
Format: Artikel
Sprache:eng
Schlagworte:
Aluminum Silicates - chemistry
DNA - chemistry
Microscopy, Atomic Force
Oligonucleotide Array Sequence Analysis
Solutions
Surface Properties
Temperature
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Zusammenfassung:This communication reports a strategy for solid surface-mediated DNA self-assembly. DNA molecules weakly interact with solid surfaces; thus are confined to solid surfaces. The confinement reduces the flexibility of DNA nanomotifs and promotes the DNA 2D crystals to grow on solid surfaces. As a demonstration, periodic DNA nanoarrays have been directly assembled onto mica surfaces. Such in situ assembly eliminates the sample transfer process between assembly and characterization and possible applications.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja906475w