Association study of the gamma-aminobutyric acid type a receptor gamma2 subunit gene with schizophrenia

Schizophrenia (SCZ) is a severe neuropsychiatric disorder with a strong genetic basis. We analyzed eight GABRG2 and one DRD5 tag single-nucleotide polymorphisms for association with SCZ in 109 small nuclear families and 229 independent SCZ case-control pairs. The marker rs183294 in the 5' regio...

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Veröffentlicht in:	Schizophrenia research 2009-10, Vol.114 (1-3), p.33-38
Hauptverfasser:	Zai, Clement C, Tiwari, Arun K, King, Nicole, De Luca, Vincenzo, Mueller, Daniel J, Shaikh, Sajid, Wong, Greg W H, Meltzer, Herbert Y, Lieberman, Jeffrey A, Kennedy, James L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Case-Control Studies DNA Mutational Analysis Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Linkage Disequilibrium Male Middle Aged Odds Ratio Polymorphism, Single Nucleotide - genetics Protein-Serine-Threonine Kinases - genetics Receptors, GABA-A - genetics Schizophrenia - genetics Young Adult
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Zusammenfassung:	Schizophrenia (SCZ) is a severe neuropsychiatric disorder with a strong genetic basis. We analyzed eight GABRG2 and one DRD5 tag single-nucleotide polymorphisms for association with SCZ in 109 small nuclear families and 229 independent SCZ case-control pairs. The marker rs183294 in the 5' region of GABRG2 was found to be associated with SCZ in both samples with the C allele over-represented in SCZ cases and over-transmitted in SCZ families (combined z=9.18; p
ISSN:	1573-2509
DOI:	10.1016/j.schres.2009.07.010