Sesquiterpenoids from Pilea cavaleriei subsp. crenata

Three new humulane-type sesquiterpenes 1– 3, and a copaborneol derivative 4 were isolated from the methanol extract of Pilea cavaleriei subsp. crenata. Their structures were elucidated and cytotoxic activities were evaluated. Three new humulane-type sesquiterpenes, 8- O-( p-coumaroyl)-5β-hydroperoxy-1(10) E,4(15)-humuladien-8 α-ol ( 1), 8- O-(3-nitro- p-coumaroyl)-1(10) E,4(15)-humuladien-5β,8 α-diol ( 2) and 8- O-( p-coumaroyl)-1(10) E,4(5) E-humuladien-8-ol ( 3), and a new copaborneol derivative, 1- O- p-coumaroyl-copaborneol ( 4), have been isolated from the methanol extract of Pilea cavaleriei Lévl. subsp. crenata C. J. Chen. Their structures were elucidated using spectroscopic methods. Cytotoxic and antimicrobial activities of the isolated compounds were evaluated.