Heterogeneous Expression of Potassium Currents and Pacemaker Currents Potentially Regulates Arrhythmogenesis of Pulmonary Vein Cardiomyocytes

Introduction: The relationship between the determining factors and beating rates of pulmonary vein (PV) pacemaker cardiomyocytes has not been fully elucidated. The purposes of this study were to compare the electrophysiological characteristics between PV fast and slow pacemaker cardiomyocytes. Methods: Whole‐cell patch clamp was used to investigate the action potentials, transient outward currents (Ito), sustained outward potassium currents (IKsus), rapid delayed rectifier potassium currents (IKr), inward rectifier potassium current (IK1), pacemaker currents (If), and transient inward currents in isolated rabbit PV single fast (≥2.5 Hz) and slow (