Brain tissue oxygen tension monitoring in pediatric severe traumatic brain injury: Part 2: Relationship with clinical, physiological, and treatment factors

Introduction Brain tissue oxygen tension (PbtO 2 ) monitoring is used increasingly in adult severe traumatic brain injury (TBI) management. Several factors are known to influence PbtO 2 in adults, but the variables that affect PbtO 2 in pediatric TBI are not well described. This study examines the relationships between PbtO 2 and (1) physiological markers of potential secondary insults commonly used in pediatric TBI, in particular intracranial pressure (ICP), cerebral perfusion pressure (CPP), and systemic hypoxia, and (2) other clinical factors and treatment received that may influence PbtO 2 . Materials and methods In this prospective observational study, 52 children (mean age, 6.5 ± 3.4 years; range, 9 months to 14 years old) with severe TBI and a median post-resuscitation Glasgow Coma Score (GCS) of 5 were managed with continuous PbtO 2 monitoring. The relationships between PbtO 2 parameters ( , PbtO 2