Administration of anti-glucagon-like peptide-2 serum suppresses epithelial cell proliferation of the distal small intestine in weanling rats

We investigated the effects of endogenous glucagon-like peptide-2 (GLP-2) on the development of intestinal mucosa in weanling rats. Three-week-old male weanling Sprague-Dawley rats were administered either anti-GLP-2 or normal rabbit serum every other day for 2 weeks. We then measured length, weight...

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Veröffentlicht in:Biomedical Research 2009, Vol.30(4), pp.259-261
Hauptverfasser: Ishizuka, Satoshi, Inafune, Ayako, Hira, Tohru, Izumi, Hirohisa, Ozawa, Kazuhiro, Takase, Mitsunori, Hara, Hiroshi
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Sprache:eng
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Zusammenfassung:We investigated the effects of endogenous glucagon-like peptide-2 (GLP-2) on the development of intestinal mucosa in weanling rats. Three-week-old male weanling Sprague-Dawley rats were administered either anti-GLP-2 or normal rabbit serum every other day for 2 weeks. We then measured length, weight, and bromodeoxyuridine incorporation in the intestine on day 13 following the first injection. Administration of anti-GLP-2 serum significantly inhibited both epithelial proliferation in the distal ileum and elongation of the small intestine. These results suggest that intrinsic GLP-2 contributes to the growth of the small intestine during the weanling period.
ISSN:0388-6107
1880-313X
DOI:10.2220/biomedres.30.259