pH-responsive mechanised nanoparticles gated by semirotaxanes

A [2]pseudorotaxane-based mechanised nanoparticle system, which operates within an aqueous acidic environment, has been prepared and characterised; this integrated system affords both water-soluble stalk and ring components in an effort to improve the biocompatibility of these promising new drug del...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2009-01 (36), p.5371-5373
Hauptverfasser:	Khashab, Niveen M, Belowich, Matthew E, Trabolsi, Ali, Friedman, Douglas C, Valente, Cory, Lau, Yuen, Khatib, Hussam A, Zink, Jeffrey I, Stoddart, J Fraser
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatible Materials - chemistry Bridged-Ring Compounds - chemistry Drug Delivery Systems - methods Hydrogen-Ion Concentration Imidazoles - chemistry Macrocyclic Compounds - chemistry Magnetic Resonance Spectroscopy Nanoparticles - chemistry Rhodamines - chemistry Rotaxanes - chemistry Silicon Dioxide - chemistry Spectrometry, Fluorescence Viologens - chemistry
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Beschreibung
Zusammenfassung:	A [2]pseudorotaxane-based mechanised nanoparticle system, which operates within an aqueous acidic environment, has been prepared and characterised; this integrated system affords both water-soluble stalk and ring components in an effort to improve the biocompatibility of these promising new drug delivery vehicles.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b910431c