Palladium-Catalyzed Direct Alkynylation of C−H Bonds in Benzenes

Palladium-Catalyzed Direct Alkynylation of C−H Bonds in Benzenes

Palladium-catalyzed ortho-alkynylation of aromatic C−H bonds in anilides is described. Preliminary mechanistic studies reveal that electrophilic palladation is involved. Synthetic elaborations of alkynylated products are also demonstrated.

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Veröffentlicht in:Organic letters 2009-08, Vol.11 (15), p.3250-3252
Hauptverfasser: Tobisu, Mamoru, Ano, Yusuke, Chatani, Naoto
Format: Artikel
Sprache:eng
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Zusammenfassung:Palladium-catalyzed ortho-alkynylation of aromatic C−H bonds in anilides is described. Preliminary mechanistic studies reveal that electrophilic palladation is involved. Synthetic elaborations of alkynylated products are also demonstrated.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol901049r