Distribution of D5 dopamine receptor mRNA in rat brain

The distribution of the messenger RNA encoding the dopamine D5 receptor was determined in the rat brain by in situ hybridization. Using [35S]-labelled riboprobes to either the rat or human D5 receptor, this mRNA was localized to the hippocampus and the parafascicular nucleus of the thalamus. This mR...

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Veröffentlicht in:	Neuroscience letters 1992-10, Vol.145 (2), p.209-212
Hauptverfasser:	MEADOR-WOODRUFF, J. H, MANSOUR, A, GRANDY, D. K, DAMASK, S. P, CIVELLI, O, WATSON, S. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy Animals Biological and medical sciences Brain Chemistry - physiology Central nervous system Fundamental and applied biological sciences. Psychology Hippocampus - anatomy & histology Hippocampus - metabolism Humans In Situ Hybridization Rats Receptors, Dopamine - genetics Receptors, Dopamine - metabolism Receptors, Dopamine D1 Receptors, Dopamine D5 RNA Probes RNA, Messenger - metabolism Thalamic Nuclei - anatomy & histology Thalamic Nuclei - metabolism Vertebrates: nervous system and sense organs
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Zusammenfassung:	The distribution of the messenger RNA encoding the dopamine D5 receptor was determined in the rat brain by in situ hybridization. Using [35S]-labelled riboprobes to either the rat or human D5 receptor, this mRNA was localized to the hippocampus and the parafascicular nucleus of the thalamus. This mRNA could not be visualized in the more traditional brain regions associated with dopaminergic cell bodies or projection fields. This unusual distribution suggests a novel function in the brain for this subtype of the dopamine receptor.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(92)90024-2