Phosphate Functional Core-Shell Polymer Nanoparticles for the Release of Vascular Endothelial Growth Factor
Nanodelivery: The controlled delivery of growth factors is an essential aspect of angiogenesis, and here we describe a particulate delivery system that provides vascular endothelial growth factor (VEGF). Core‐shell nanoparticles composed of polystyrene cores and cross‐linked polymers of an alkenyl p...
Gespeichert in:
| Veröffentlicht in: | Chembiochem : a European journal of chemical biology 2009-09, Vol.10 (13), p.2165-2170 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2170 |
|---|---|
| container_issue | 13 |
| container_start_page | 2165 |
| container_title | Chembiochem : a European journal of chemical biology |
| container_volume | 10 |
| creator | Gilmore, Louisa MacNeil, Sheila Rimmer, Stephen |
| description | Nanodelivery: The controlled delivery of growth factors is an essential aspect of angiogenesis, and here we describe a particulate delivery system that provides vascular endothelial growth factor (VEGF). Core‐shell nanoparticles composed of polystyrene cores and cross‐linked polymers of an alkenyl phosphate bind and release VEGF and highly basic peptide sequences. VEGF was released over several days in a bioactive form. |
| doi_str_mv | 10.1002/cbic.200900383 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734022284</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>734022284</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3683-a88da61d9cc9c65523c25855482b8ea3e940404945dbdc6edfbd9f2bf4690af13</originalsourceid><addsrcrecordid>eNqFkU1v1DAURS0EoqWwZQnescrgr3jiJUSdUqmCilK21ovzTAKeeGonqubf42pGlF3lhS29c4_0rgl5y9mKMyY-um50K8GYYUw28hk55Uqaaq2lfH58KyHWJ-RVzr9ZwbTkL8kJN1opY_Qp-XM9xLwbYEa6WSY3j3GCQNuYsLoZMAR6HcN-i4l-hSnuIM2jC5ipj4nOA9LvGBAy0ujpT8huCZDo-dTHMgtjEV2keD8PdANujuk1eeEhZHxzvM_I7eb8R_uluvp2cdl-uqqc1I2soGl60Lw3zhmn61pIJ-qmrlUjugZBolGsHKPqvuudxt53vfGi80obBp7LM_Lh4N2leLdgnu12zK4sAxPGJdu1VEwI0ahCrg6kSzHnhN7u0riFtLec2Yd-7UO_9l-_JfDuqF66LfaP-LHQApgDcD8G3D-hs-3ny_Z_-ftD1kO08CuN2d7eCMYl43qtyz_Kv4D8kX0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734022284</pqid></control><display><type>article</type><title>Phosphate Functional Core-Shell Polymer Nanoparticles for the Release of Vascular Endothelial Growth Factor</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Gilmore, Louisa ; MacNeil, Sheila ; Rimmer, Stephen</creator><creatorcontrib>Gilmore, Louisa ; MacNeil, Sheila ; Rimmer, Stephen</creatorcontrib><description>Nanodelivery: The controlled delivery of growth factors is an essential aspect of angiogenesis, and here we describe a particulate delivery system that provides vascular endothelial growth factor (VEGF). Core‐shell nanoparticles composed of polystyrene cores and cross‐linked polymers of an alkenyl phosphate bind and release VEGF and highly basic peptide sequences. VEGF was released over several days in a bioactive form.</description><identifier>ISSN: 1439-4227</identifier><identifier>EISSN: 1439-7633</identifier><identifier>DOI: 10.1002/cbic.200900383</identifier><identifier>PMID: 19644996</identifier><language>eng</language><publisher>Weinheim: Wiley-VCH Verlag</publisher><subject>Amino Acid Sequence ; controlled release ; Drug Carriers - chemistry ; drug delivery ; growth factors ; Molecular Imprinting ; nanoparticles ; Nanoparticles - chemistry ; Peptides - metabolism ; Phosphates - chemistry ; Polystyrenes - chemistry ; Protein Binding ; Vascular Endothelial Growth Factor A - administration & dosage ; VEGF</subject><ispartof>Chembiochem : a European journal of chemical biology, 2009-09, Vol.10 (13), p.2165-2170</ispartof><rights>Copyright © 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3683-a88da61d9cc9c65523c25855482b8ea3e940404945dbdc6edfbd9f2bf4690af13</citedby><cites>FETCH-LOGICAL-c3683-a88da61d9cc9c65523c25855482b8ea3e940404945dbdc6edfbd9f2bf4690af13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbic.200900383$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbic.200900383$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19644996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gilmore, Louisa</creatorcontrib><creatorcontrib>MacNeil, Sheila</creatorcontrib><creatorcontrib>Rimmer, Stephen</creatorcontrib><title>Phosphate Functional Core-Shell Polymer Nanoparticles for the Release of Vascular Endothelial Growth Factor</title><title>Chembiochem : a European journal of chemical biology</title><addtitle>Chembiochem</addtitle><description>Nanodelivery: The controlled delivery of growth factors is an essential aspect of angiogenesis, and here we describe a particulate delivery system that provides vascular endothelial growth factor (VEGF). Core‐shell nanoparticles composed of polystyrene cores and cross‐linked polymers of an alkenyl phosphate bind and release VEGF and highly basic peptide sequences. VEGF was released over several days in a bioactive form.</description><subject>Amino Acid Sequence</subject><subject>controlled release</subject><subject>Drug Carriers - chemistry</subject><subject>drug delivery</subject><subject>growth factors</subject><subject>Molecular Imprinting</subject><subject>nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Peptides - metabolism</subject><subject>Phosphates - chemistry</subject><subject>Polystyrenes - chemistry</subject><subject>Protein Binding</subject><subject>Vascular Endothelial Growth Factor A - administration & dosage</subject><subject>VEGF</subject><issn>1439-4227</issn><issn>1439-7633</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAURS0EoqWwZQnescrgr3jiJUSdUqmCilK21ovzTAKeeGonqubf42pGlF3lhS29c4_0rgl5y9mKMyY-um50K8GYYUw28hk55Uqaaq2lfH58KyHWJ-RVzr9ZwbTkL8kJN1opY_Qp-XM9xLwbYEa6WSY3j3GCQNuYsLoZMAR6HcN-i4l-hSnuIM2jC5ipj4nOA9LvGBAy0ujpT8huCZDo-dTHMgtjEV2keD8PdANujuk1eeEhZHxzvM_I7eb8R_uluvp2cdl-uqqc1I2soGl60Lw3zhmn61pIJ-qmrlUjugZBolGsHKPqvuudxt53vfGi80obBp7LM_Lh4N2leLdgnu12zK4sAxPGJdu1VEwI0ahCrg6kSzHnhN7u0riFtLec2Yd-7UO_9l-_JfDuqF66LfaP-LHQApgDcD8G3D-hs-3ny_Z_-ftD1kO08CuN2d7eCMYl43qtyz_Kv4D8kX0</recordid><startdate>20090904</startdate><enddate>20090904</enddate><creator>Gilmore, Louisa</creator><creator>MacNeil, Sheila</creator><creator>Rimmer, Stephen</creator><general>Wiley-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090904</creationdate><title>Phosphate Functional Core-Shell Polymer Nanoparticles for the Release of Vascular Endothelial Growth Factor</title><author>Gilmore, Louisa ; MacNeil, Sheila ; Rimmer, Stephen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3683-a88da61d9cc9c65523c25855482b8ea3e940404945dbdc6edfbd9f2bf4690af13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Amino Acid Sequence</topic><topic>controlled release</topic><topic>Drug Carriers - chemistry</topic><topic>drug delivery</topic><topic>growth factors</topic><topic>Molecular Imprinting</topic><topic>nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Peptides - metabolism</topic><topic>Phosphates - chemistry</topic><topic>Polystyrenes - chemistry</topic><topic>Protein Binding</topic><topic>Vascular Endothelial Growth Factor A - administration & dosage</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gilmore, Louisa</creatorcontrib><creatorcontrib>MacNeil, Sheila</creatorcontrib><creatorcontrib>Rimmer, Stephen</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chembiochem : a European journal of chemical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gilmore, Louisa</au><au>MacNeil, Sheila</au><au>Rimmer, Stephen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phosphate Functional Core-Shell Polymer Nanoparticles for the Release of Vascular Endothelial Growth Factor</atitle><jtitle>Chembiochem : a European journal of chemical biology</jtitle><addtitle>Chembiochem</addtitle><date>2009-09-04</date><risdate>2009</risdate><volume>10</volume><issue>13</issue><spage>2165</spage><epage>2170</epage><pages>2165-2170</pages><issn>1439-4227</issn><eissn>1439-7633</eissn><abstract>Nanodelivery: The controlled delivery of growth factors is an essential aspect of angiogenesis, and here we describe a particulate delivery system that provides vascular endothelial growth factor (VEGF). Core‐shell nanoparticles composed of polystyrene cores and cross‐linked polymers of an alkenyl phosphate bind and release VEGF and highly basic peptide sequences. VEGF was released over several days in a bioactive form.</abstract><cop>Weinheim</cop><pub>Wiley-VCH Verlag</pub><pmid>19644996</pmid><doi>10.1002/cbic.200900383</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1439-4227 |
| ispartof | Chembiochem : a European journal of chemical biology, 2009-09, Vol.10 (13), p.2165-2170 |
| issn | 1439-4227 1439-7633 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734022284 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Amino Acid Sequence controlled release Drug Carriers - chemistry drug delivery growth factors Molecular Imprinting nanoparticles Nanoparticles - chemistry Peptides - metabolism Phosphates - chemistry Polystyrenes - chemistry Protein Binding Vascular Endothelial Growth Factor A - administration & dosage VEGF |
| title | Phosphate Functional Core-Shell Polymer Nanoparticles for the Release of Vascular Endothelial Growth Factor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T16%3A36%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Phosphate%20Functional%20Core-Shell%20Polymer%20Nanoparticles%20for%20the%20Release%20of%20Vascular%20Endothelial%20Growth%20Factor&rft.jtitle=Chembiochem%20:%20a%20European%20journal%20of%20chemical%20biology&rft.au=Gilmore,%20Louisa&rft.date=2009-09-04&rft.volume=10&rft.issue=13&rft.spage=2165&rft.epage=2170&rft.pages=2165-2170&rft.issn=1439-4227&rft.eissn=1439-7633&rft_id=info:doi/10.1002/cbic.200900383&rft_dat=%3Cproquest_cross%3E734022284%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=734022284&rft_id=info:pmid/19644996&rfr_iscdi=true |