Phosphate Functional Core-Shell Polymer Nanoparticles for the Release of Vascular Endothelial Growth Factor

Phosphate Functional Core-Shell Polymer Nanoparticles for the Release of Vascular Endothelial Growth Factor

Nanodelivery: The controlled delivery of growth factors is an essential aspect of angiogenesis, and here we describe a particulate delivery system that provides vascular endothelial growth factor (VEGF). Core‐shell nanoparticles composed of polystyrene cores and cross‐linked polymers of an alkenyl p...

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Veröffentlicht in:Chembiochem : a European journal of chemical biology 2009-09, Vol.10 (13), p.2165-2170
Hauptverfasser: Gilmore, Louisa, MacNeil, Sheila, Rimmer, Stephen
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
controlled release
Drug Carriers - chemistry
drug delivery
growth factors
Molecular Imprinting
nanoparticles
Nanoparticles - chemistry
Peptides - metabolism
Phosphates - chemistry
Polystyrenes - chemistry
Protein Binding
Vascular Endothelial Growth Factor A - administration & dosage
VEGF
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Zusammenfassung:Nanodelivery: The controlled delivery of growth factors is an essential aspect of angiogenesis, and here we describe a particulate delivery system that provides vascular endothelial growth factor (VEGF). Core‐shell nanoparticles composed of polystyrene cores and cross‐linked polymers of an alkenyl phosphate bind and release VEGF and highly basic peptide sequences. VEGF was released over several days in a bioactive form.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.200900383