Imaging of regional metabolic activity by (18)F-FDG/PET in rats with transient cerebral ischemia

Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that (18)F-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-a...

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Veröffentlicht in:	Applied radiation and isotopes 2009-10, Vol.67 (10), p.1743-1747
Hauptverfasser:	Fu, Ying-Kai, Chang, Chia-Jung, Chen, Kuan-Yin, Hwang, Li-Chung, Wu, Kuo-Hung, Chang, Kang-Wei, Jan, Meei-Ling, Chen, Chia-Chieh, Chang, Chih-Hsien
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Fluorine Radioisotopes Fluorodeoxyglucose F18 - metabolism Infarction, Middle Cerebral Artery - metabolism Ischemic Attack, Transient - diagnostic imaging Ischemic Attack, Transient - metabolism Male Positron-Emission Tomography Rats Rats, Sprague-Dawley
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Zusammenfassung:	Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that (18)F-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with (18)F-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents.
ISSN:	1872-9800
DOI:	10.1016/j.apradiso.2009.03.002