Myeloperoxidase concentrations in EDTA-plasma of healthy subjects are discordant with concentrations in heparin-plasma and serum

To examine the effect of blood anticoagulation type on the myeloperoxidase (MPO) concentration. MPO was measured in EDTA-plasma and matched heparin-plasma and serum samples collected from healthy volunteers. MPO concentrations in heparin-plasma and serum were higher than in EDTA-plasma (both P <...

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Veröffentlicht in:Clinical biochemistry 2009-09, Vol.42 (13), p.1490-1492
Hauptverfasser: Scheffer, Peter G., van der Zwan, Leonard P., Schindhelm, Roger K., Vermue, Hendrikus P.A., Teerlink, Tom
Format: Artikel
Sprache:eng
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Zusammenfassung:To examine the effect of blood anticoagulation type on the myeloperoxidase (MPO) concentration. MPO was measured in EDTA-plasma and matched heparin-plasma and serum samples collected from healthy volunteers. MPO concentrations in heparin-plasma and serum were higher than in EDTA-plasma (both P < 0.001). MPO in EDTA-plasma was not significantly correlated with MPO in either heparin-plasma or serum. For MPO measurements, EDTA-plasma is the preferred specimen as it appears unaffected by ex vivo release of MPO from leukocytes.
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2009.06.004