A Simple and Convenient Copper-Catalyzed Tandem Synthesis of Quinoline-2-carboxylates at Room Temperature

We developed a simple and convenient copper-catalyzed method for the synthesis of quinoline-2-carboxylate derivatives through sequential intermolecular addition of alkynes onto imines and subsequent intramolecular ring closure by arylation. The efficiency of this system allowed the reactions to be c...

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Veröffentlicht in:	Journal of organic chemistry 2009-08, Vol.74 (15), p.5476-5480
Hauptverfasser:	Huang, He, Jiang, Hualiang, Chen, Kaixian, Liu, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Catalysis Chemistry Copper - chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Imines - chemistry Organic chemistry Organometallic Compounds - chemistry Preparations and properties Quinolines - chemical synthesis Quinolines - chemistry Stereoisomerism Temperature
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Beschreibung
Zusammenfassung:	We developed a simple and convenient copper-catalyzed method for the synthesis of quinoline-2-carboxylate derivatives through sequential intermolecular addition of alkynes onto imines and subsequent intramolecular ring closure by arylation. The efficiency of this system allowed the reactions to be carried out at room temperature.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo901101v