Notch Signalling: Receptor cis-Inhibition To Achieve Directionality

Lateral inhibition, by which single cells become distinct from their neighbours, can be mediated by Notch signalling during animal development. Signalling directionality is presumably achieved by downregulation of the Notch ligand in signal-receiving cells. New evidence suggests that cis-inhibition...

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Veröffentlicht in:	Current biology 2009-08, Vol.19 (16), p.R683-R684
Hauptverfasser:	del Álamo, David, Schweisguth, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Communication Cell Lineage Compound Eye, Arthropod - cytology Compound Eye, Arthropod - growth & development Drosophila melanogaster - cytology Drosophila melanogaster - growth & development Drosophila Proteins - physiology Epidermal Growth Factor - physiology Feedback, Physiological Intracellular Signaling Peptides and Proteins Membrane Proteins - physiology Models, Biological Photoreceptor Cells, Invertebrate - cytology Photoreceptor Cells, Invertebrate - metabolism Receptors, Notch - physiology Signal Transduction - physiology
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Beschreibung
Zusammenfassung:	Lateral inhibition, by which single cells become distinct from their neighbours, can be mediated by Notch signalling during animal development. Signalling directionality is presumably achieved by downregulation of the Notch ligand in signal-receiving cells. New evidence suggests that cis-inhibition of the receptor in the ligand-sending cell might also provide directionality.
ISSN:	0960-9822 1879-0445
DOI:	10.1016/j.cub.2009.07.025