Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives

Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal. The activities of these compounds were investigated against several glycosidase enzymes and showed moderate inhi...

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Veröffentlicht in:	Carbohydrate research 2009-09, Vol.344 (13), p.1639-1645
Hauptverfasser:	Chir, Jiun-Ly, Wu, Pey-Jiuann, Zou, Wei, Bhasin, Milan, Juang, Wei-Fu, Guo, Chao-Qi, Wu, An-Tai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bicyclic Bridged Bicyclo Compounds, Heterocyclic - chemistry C-Glycoside Cattle Enzyme Activation - drug effects Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Ether bridge Ethers - chemistry Glycosidase Glycoside Hydrolases - antagonists & inhibitors Imino Sugars - chemical synthesis Imino Sugars - chemistry Imino Sugars - pharmacology Iminosugar
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Zusammenfassung:	Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal. The activities of these compounds were investigated against several glycosidase enzymes and showed moderate inhibition and activation.
ISSN:	0008-6215 1873-426X
DOI:	10.1016/j.carres.2009.05.029