Cross-linked Peptoid-Based Dimerization Inhibitors of HIV-1 Protease

Peptoid‐based agents that target viral protein–protein interactions within the dimerization interface of HIV‐1 protease (PR) are disclosed. The potency obtained is quite remarkable considering that five side‐chain moieties were relocated in the peptoid structures, and the hydrogen‐bonding network wi...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2010-07, Vol.11 (11), p.1513-1516
Hauptverfasser:	Lee, Song-Gil, Chmielewski, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-sheets Dimerization HIV protease dimerization HIV Protease Inhibitors - chemistry Humans Hydrogen Bonding Molecular Structure peptidomimetics peptoids Peptoids - chemistry Peptoids - pharmacology Peptoids - therapeutic use Protein Binding - drug effects protein-protein interactions Structure-Activity Relationship
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