Cross-linked Peptoid-Based Dimerization Inhibitors of HIV-1 Protease

Cross-linked Peptoid-Based Dimerization Inhibitors of HIV-1 Protease

Peptoid‐based agents that target viral protein–protein interactions within the dimerization interface of HIV‐1 protease (PR) are disclosed. The potency obtained is quite remarkable considering that five side‐chain moieties were relocated in the peptoid structures, and the hydrogen‐bonding network wi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chembiochem : a European journal of chemical biology 2010-07, Vol.11 (11), p.1513-1516
Hauptverfasser: Lee, Song-Gil, Chmielewski, Jean
Format: Artikel
Sprache:eng
Schlagworte:
beta-sheets
Dimerization
HIV protease dimerization
HIV Protease Inhibitors - chemistry
Humans
Hydrogen Bonding
Molecular Structure
peptidomimetics
peptoids
Peptoids - chemistry
Peptoids - pharmacology
Peptoids - therapeutic use
Protein Binding - drug effects
protein-protein interactions
Structure-Activity Relationship
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Peptoid‐based agents that target viral protein–protein interactions within the dimerization interface of HIV‐1 protease (PR) are disclosed. The potency obtained is quite remarkable considering that five side‐chain moieties were relocated in the peptoid structures, and the hydrogen‐bonding network within the dimerization interface was compromised. These data show the importance of inhibitor side‐chain interactions with HIV‐1 PR.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201000248