l-Histidine and l-arginine promote Knoevenagel reaction in water

Histidine and arginine were applied to the synthesis of trisubstituted alkenes through a condensation of an aldehyde with an activated CH-acid such as ethyl cyanoacetate, malononitrile, acetyl acetone or ethyl acetoacetate during 5-12 h in water at room temperature.

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Veröffentlicht in:Amino acids 2010-08, Vol.39 (3), p.911-916
Hauptverfasser: Rahmati, Abbas, Vakili, Kobra
Format: Artikel
Sprache:eng
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Zusammenfassung:Histidine and arginine were applied to the synthesis of trisubstituted alkenes through a condensation of an aldehyde with an activated CH-acid such as ethyl cyanoacetate, malononitrile, acetyl acetone or ethyl acetoacetate during 5-12 h in water at room temperature.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-010-0537-z