Dual Regulation of Proton‐ and Sodium‐Coupled Phosphate Transport Systems in the Yarrowia lipolytica Yeast by Extracellular Phosphate and pH

In this study we used a newly isolated osmo‐, salt‐, and alkali‐tolerant Yarrowia lipolytica yeast strain, with a unique capacity to grow over a wide pH range (3.5‐10.5). A procedure was elaborated to follow phosphate accumulation by Y. lipolytica cells grown at different pH values. In this paper we demonstrate that Pi‐starved Y. lipolytica cells are endowed by derepressible high‐affinity, high‐capacity H+‐ and Na+‐driven Pi uptake systems and that activities of these transport systems are under the dual control by the prevailing extracellular Pi concentrations and pH values. IUBMB Life, 55: 151‐154, 2003