Ceratinadins A–C, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp

Three new bromotyrosine alkaloids, ceratinadins A–C (1–3), were isolated from an Okinawan marine sponge Pseudoceratina sp. and the structures of 1–3 were elucidated on the basis of spectroscopic data. Ceratinadin A (1) was a novel bromotyrosine alkaloid possessing an N-imidazolyl-quinolinone moiety....

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2010-08, Vol.20 (15), p.4569-4572
Hauptverfasser: Kon, Yuji, Kubota, Takaaki, Shibazaki, Azusa, Gonoi, Tohru, Kobayashi, Jun’ichi
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Sprache:eng
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Zusammenfassung:Three new bromotyrosine alkaloids, ceratinadins A–C (1–3), were isolated from an Okinawan marine sponge Pseudoceratina sp. and the structures of 1–3 were elucidated on the basis of spectroscopic data. Ceratinadin A (1) was a novel bromotyrosine alkaloid possessing an N-imidazolyl-quinolinone moiety. Ceratinadins A (1) and B (2) showed antifungal activity.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2010.06.015